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浅埋大跨公路隧道穿越富水软弱土层施工关键技术

赵立财

《中国工程科学》 2015年 第17卷 第1期   页码 81-87

摘要：

以厦漳公路（厦门段）东孚隧道施工为例，介绍了?229大管棚跟管钻进咬合相接加固技术+十字交叉隔壁后拆式开挖技术在浅埋富水软弱土层隧道开挖过程中的应用；同时利用TGMIS动态智能化监测系统对施工沉降状况进行了数据采集、分析及处理，使围岩变形得到控制，顺利通过了浅埋软弱土层段掘进施工。

关键词： 浅埋；富水软弱土；隧道；管棚；加固；十字交叉隔壁后拆式；开挖    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

《医学前沿（英文）》 2022年 第16卷 第1期   页码 17-24 doi: 10.1007/s11684-021-0873-2

摘要： Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is a kind of human glucagon-like peptide-1 (GLP-1) analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism. GLP-1 can also delay stomach emptying and suppress appetite to help lose weight. This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.

关键词： semaglutide     type 2 diabetes     obesity    

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Personalized medicine of type 2 diabetes

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 1-3 doi: 10.1007/s11684-013-0241-y

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Assessment of glass fiber-reinforced polyester pipe powder in soil improvement

《结构与土木工程前沿（英文）》 2021年 第15卷 第3期   页码 742-753 doi: 10.1007/s11709-021-0732-x

摘要： This study investigates the use of glass fiber-reinforced polyester (GRP) pipe powder (PP) for improving the bearing capacity of sandy soils. After a series of direct share tests, the optimum PP addition for improving the bearing capacity of soils was found to be 12%. Then, using the optimum PP addition, the bearing capacity of the soil was estimated through a series of loading tests on a shallow foundation model placed in a test box. The bearing capacity of sandy soil was improved by up to 30.7%. The ratio of the depth of the PP-reinforced soil to the diameter of the foundation model (H/D) of 1.25 could sufficiently strengthen sandy soil when the optimum PP ratio was used. Microstructural analyses showed that the increase in the bearing capacity can be attributed to the chopped fibers in the PP and their multiaxial distribution in the soil. Besides improving the engineering properties of soils, using PP as an additive in soils would reduce the accumulation of the industrial waste, thus providing a twofold benefit.

关键词： shallow foundation     sandy soil     bearing capacity     soil improvement     pipe powder    

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A new procedure combining GC-MS with accelerated solvent extraction for the analysis of phthalic acid esters in contaminated soils

Tingting MA, Ying TENG, Peter CHRISTIE, Yongming LUO, Yongshan CHEN, Mao YE, Yujuan HUANG

《环境科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 31-42 doi: 10.1007/s11783-012-0463-2

摘要： An optimized procedure based on gas chromatography-mass spectrometry (GC-MS) combined with accelerated solvent extraction (ASE) is developed for the analysis of six phthalic acid esters (PAEs), which are priority soil pollutants nominated by United States Environmental Protection Agency (USEPA). Quantification of PAEs in soil employs ultrasonic extraction (UE) (USEPA 3550) and ASE (USEPA 3545), followed by clean up procedures involving three different chromatography columns and two combined elution methods. GC-MS conditions under selected ion monitoring (SIM) mode are described and quality assurance and quality control (QA/QC) criteria with high accuracy and sensitivity for target analytes were achieved. Method reliability is assured with the use of an isotopically labeled PAE, di- -butyl phthalate-d4 (DnBP-D4), as a surrogate, and benzyl benzoate (BB) as an internal standard, and with the analysis of certified reference materials (CRM). QA/QC for the developed procedure was tested in four PAE-spiked soils and one PAE-contaminated soil. The four spiked soils were originated from typical Chinese agricultural fields and the contaminated soil was obtained from an electronic waste dismantling area. Instrument detection limits (IDLs) for the six PAEs ranged 0.10–0.31 μg·L and method detection limits (MDLs) of the four spiked soils varied from a range of 20–70 μg·kg to a range of 90– 290 μg·kg . Linearity of response between 20 μg·L and 2 mg·L was also established and the correlation coefficients ( ) were all>0.998. Spiked soil matrix showed relative recovery rates between 75 and 120% for the six target compounds and about 93% for the surrogate substance. The developed procedure is anticipated to be highly applicable for field surveys of soil PAE pollution in China.

关键词： phthalic acid esters     quality assurance and quality control     soil type     accelerated solvent extraction     certified reference materials    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

null

《医学前沿（英文）》 2017年 第11卷 第4期   页码 480-489 doi: 10.1007/s11684-017-0594-8

摘要：

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

关键词： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns

Hiruy ABDU, David A. ROBINSON, Janis BOETTINGER, Scott B. JONES

《农业科学与工程前沿（英文）》 2017年 第4卷 第2期   页码 135-145 doi: 10.15302/J-FASE-2017143

摘要： Knowledge of the spatial distribution of soil textural properties is important for determining soil moisture storage and soil hydraulic transport properties. Capturing field heterogeneity without exhaustive sampling and costly sample analysis is difficult. Our objective was to employ electromagnetic induction (EMI) mapping in low apparent electrical conductivity (EC ) soils at varying soil water contents to capture time invariant properties such as soil texture. Georeferenced EC measurements were taken using a ground conductivity meter on six different days where volumetric water content ( ) varied from 0.11 to 0.23. The 50 m × 50 m field included a subsurface gravelly patch in an otherwise homogeneous silt-loam alluvial soil. Ordinary block kriging predicted EC at unsampled areas to produce 1-m resolution maps. Temporal stability analysis was used to divide the field into three distinct EC regions. Subsequent ground-truthing confirmed the lowest conductivity region correlated with coarse textured soil parent materials associated with a former high-energy alluvial depositional area. Combining maps using temporal stability analysis gives the clearest image of the textural difference. These maps could be informative for modeling, experimental design, sensor placement and targeted zone management strategies in soil science, ecology, hydrology, and agricultural applications.

关键词： soil electrical conductivity     soil texture mapping     temporal stability analysis    

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Metabolomics in human type 2 diabetes research

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 4-13 doi: 10.1007/s11684-013-0248-4

摘要：

The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.

关键词： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 1071-1071 doi: 10.1007/s11709-021-0736-6

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SOIL CARBON CHECK: A TOOL FOR MONITORING AND GUIDING SOIL CARBON SEQUESTRATION IN FARMER FIELDS

《农业科学与工程前沿（英文）》 2023年 第10卷 第2期   页码 248-261 doi: 10.15302/J-FASE-2023499

摘要：

● Establishment of a rapid tool for monitoring soil carbon sequestration in farmer fields.

关键词： 4 per 1000 initiative     carbon sequestration     climate action     farmer fields     SDG13     soil organic carbon     soil testing    

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Adsorption behavior of antibiotic in soil environment: a critical review

Shiliang WANG,Hui WANG

《环境科学与工程前沿（英文）》 2015年 第9卷 第4期   页码 565-574 doi: 10.1007/s11783-015-0801-2

摘要： Antibiotics are used widely in human and veterinary medicine, and are ubiquitous in environment matrices worldwide. Due to their consumption, excretion, and persistence, antibiotics are disseminated mostly via direct and indirect emissions such as excrements, sewage irrigation, and sludge compost and enter the soil and impact negatively the natural ecosystem of soil. Most antibiotics are amphiphilic or amphoteric and ionize. A non-polar core combined with polar functional moieties makes up numerous antibiotic molecules. Because of various molecule structures, physicochemical properties vary widely among antibiotic compounds. Sorption is an important process for the environment behaviors and fate of antibiotics in soil environment. The adsorption process has decisive role for the environmental behaviors and the ultimate fates of antibiotics in soil. Multiply physicochemical properties of antibiotics induce the large variations of their adsorption behaviors. In addition, factors of soil environment such as the pH, ionic strength, metal ions, and organic matter content also strongly impact the adsorption processes of antibiotics. Review about adsorption of antibiotics on soil can provide a fresh insight into understanding the antibiotic-soil interactions. Therefore, literatures about the adsorption mechanisms of antibiotics in soil environment and the effects of environment factors on adsorption behaviors of antibiotics in soil are reviewed and discussed systematically in this review.

关键词： adsorption     antibiotics     environment factors     soil    

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A simplified method for the determination of vertically loaded pile-soil interface parameters in layeredsoil based on FLAC

Jiu-jiang WU,Yan LI,Qian-gong CHENG,Hua WEN,Xin LIANG

《结构与土木工程前沿（英文）》 2016年 第10卷 第1期   页码 103-111 doi: 10.1007/s11709-015-0328-4

摘要： The numerical analysis of pile-soil interaction commonly requires a lot of trial works to determine the interface parameters and the accuracy cannot be ensured normally. Considering this, this paper first conducts a sensitivity analysis to figure out the influence of interface parameters on the bearing behavior of a single pile in sand. Then, a simplified method for the determination of pile-soil interface parameters in layered soil is proposed based on the parameter studies. Finally, a filed loading test is used for the validation of the simplified method, and the calculated results agree well with the monitoring data. In general, the simplified method proposed in this paper works with higher accuracy and consumes less time compared with the traditional trial works, especially on the determinations of interfacial cohesive and interfacial friction angle.

关键词： determination of interface parameters     pile-soil interaction     FLAC3D     sensitivity analysis     layered soil    

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Fictitious soil pile model for dynamic analysis of pipe piles under high-strain conditions

《结构与土木工程前沿（英文）》   页码 915-934 doi: 10.1007/s11709-023-0907-8

摘要： A fictitious soil pile (FSP) model is developed to simulate the behavior of pipe piles with soil plugs undergoing high-strain dynamic impact loading. The developed model simulates the base soil with a fictitious hollow pile fully filled with a soil plug extending at a cone angle from the pile toe to the bedrock. The friction on the outside and inside of the pile walls is distinguished using different shaft models, and the propagation of stress waves in the base soil and soil plug is considered. The motions of the pile−soil system are solved by discretizing them into spring-mass model based on the finite difference method. Comparisons of the predictions of the proposed model and conventional numerical models, as well as measurements for pipe piles in field tests subjected to impact loading, validate the accuracy of the proposed model. A parametric analysis is conducted to illustrate the influence of the model parameters on the pile dynamic response. Finally, the effective length of the FSP is proposed to approximate the affected soil zone below the pipe pile toe, and some guidance is provided for the selection of the model parameters.

关键词： fictitious soil pile     soil plug     pipe piles     high-strain dynamic analysis     one-dimensional wave theory     pile dynamics    

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Soil-water interaction in unsaturated expansive soil slopes

ZHAN Liangtong

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 198-204 doi: 10.1007/s11709-007-0023-1

摘要： The intensive soil-water interaction in unsaturated expansive soil is one of the major reasons for slope failures. In this paper, the soil-water interaction is investigated with the full-scale field inspection of rainwater infiltration and comprehensive experiments, including wetting-induced softening tests, swelling, and shrinkage tests. It is demonstrated that the soil-water interaction induced by seasonal wetting-drying cycles is very complex, and it involves coupled effects among the changes in water content, suction, stress, deformation and shear strength. In addition, the abundant cracks in the expansive soil play an important role in the soil-water interaction. The cracks disintegrate the soil mass, and more importantly, provide easy pathways for rainfall infiltration. Infiltration of rainwater not only results in wetting-induced softening of the shallow unsaturated soil layers, but also leads to the increase of horizontal stress. The increase of horizontal stress may lead to a local passive failure. The seasonal wetting-drying cycles tend to result in a down-slope creeping of the shallow soil layer, which leads to progressive slope failure.

关键词： strength     intensive soil-water     comprehensive     Infiltration     wetting-induced softening    

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The mechanisms linking adiposopathy to type 2 diabetes

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 433-444 doi: 10.1007/s11684-013-0288-9

摘要：

Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.

关键词： obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

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标题 作者 时间 类型 操作

浅埋大跨公路隧道穿越富水软弱土层施工关键技术

赵立财

期刊论文

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

期刊论文

Personalized medicine of type 2 diabetes

null

期刊论文

Assessment of glass fiber-reinforced polyester pipe powder in soil improvement

期刊论文

A new procedure combining GC-MS with accelerated solvent extraction for the analysis of phthalic acid esters in contaminated soils

Tingting MA, Ying TENG, Peter CHRISTIE, Yongming LUO, Yongshan CHEN, Mao YE, Yujuan HUANG

期刊论文

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

null

期刊论文

Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns

Hiruy ABDU, David A. ROBINSON, Janis BOETTINGER, Scott B. JONES

期刊论文

Metabolomics in human type 2 diabetes research

null

期刊论文

Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

期刊论文

SOIL CARBON CHECK: A TOOL FOR MONITORING AND GUIDING SOIL CARBON SEQUESTRATION IN FARMER FIELDS

期刊论文

Adsorption behavior of antibiotic in soil environment: a critical review

Shiliang WANG,Hui WANG

期刊论文

A simplified method for the determination of vertically loaded pile-soil interface parameters in layeredsoil based on FLAC

Jiu-jiang WU,Yan LI,Qian-gong CHENG,Hua WEN,Xin LIANG

期刊论文

Fictitious soil pile model for dynamic analysis of pipe piles under high-strain conditions

期刊论文

Soil-water interaction in unsaturated expansive soil slopes

ZHAN Liangtong

期刊论文

The mechanisms linking adiposopathy to type 2 diabetes

null

期刊论文